Pacritinib
Pacritinib (SB1518) is a potent and selective small molecule inhibitor targeting JAK2 and FLT3 kinases, with cell-free assay IC50 values of 23 nM and 22 nM, respectively. It is widely used in preclinical research for studying myeloproliferative neoplasms and acute myeloid leukemia, demonstrating activity in both cellular assays and in vivo models.
Product Specifications
CAS Number
937272-79-2
Product Name Alternative
Inhibitor, Fms like tyrosine kinase 3, FLT3, FLT3 (D835Y), Janus kinase, JAK3, JAK2 (V617F), JAK, JAK2, inhibit, Pacritinib, Cluster of differentiation antigen 135, CD135, SB 1518, SB1518, SB-1518, TyrosineKinases, Tyrosine Kinases, Tyk2
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
≥95% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.12 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:3.57 mg/mL (7.55 mM)
Smiles
C (CN1CCCC1) Oc1ccc2Nc3nccc (n3) -c3cccc (COC\C=C\COCc1c2) c3
Molecular Formula
C28H32N4O3
Molecular Weight
472.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
144242-HRP 100 µL
BMPR1A (Acvrlk3, Bmpr, CD292, ALK-3, BMPR-1A, BMP type-1A receptor, SKR5, Activin receptor-like kinase 3, BMP-2/BMP-4 receptor, Serine/threonine-protein kinase receptor R5, ACTIVIN A RECEPTOR, TYPE II-LIKE KINASE 3) (HRP) discontinued
Sign In for Pricing
View Details MBS6317102-01 0.2 mL
LRRC38, CT (LRRC38, Leucine-rich repeat-containing protein 38, BK channel auxilliary gamma subunit LRRC38) (Azide free) (HRP)
Sign In for Pricing
View Details MBS6317102-02 5x 0.2 mL
LRRC38, CT (LRRC38, Leucine-rich repeat-containing protein 38, BK channel auxilliary gamma subunit LRRC38) (Azide free) (HRP)
Sign In for Pricing
View Details