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GSK1324726A

GSK1324726A (I-BET726) is a potent and selective BET bromodomain inhibitor, exhibiting IC50 values of 41 nM, 31 nM, and 22 nM for BRD2, BRD3, and BRD4, respectively. This tool compound is widely used in vitro and in vivo to investigate BET protein function in oncology, immunology, and inflammatory disease research.

Product Specifications

CAS Number

1300031-52-0

Product Name Alternative

BRD2, BRD3, BRD4, Apoptosis, inhibit, Inhibitor, I-BET 726, I-BET726, I-BET-726, GSK1324726A, GSK-1324726A, Epigenetic Reader Domain, EpigeneticReaderDomain

Field of Research

Cell Biology, Epigenetics & Chromatin

Purity

98.34% (May vary between batches)

Solubility

DMSO:50 mg/mL (114.97 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.6 mM) ; Ethanol:80 mg/mL (183.95 mM)

Smiles

C (C) (=O) N1C=2C ([C@H] (NC3=CC=C (Cl) C=C3) C[C@@H]1C) =CC (=CC2) C4=CC=C (C (O) =O) C=C4

Molecular Formula

C25H23ClN2O3

Molecular Weight

434.91

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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