Zoligratinib
Zoligratinib (CH5183284) is an orally bioavailable, selective FGFR inhibitor with IC50 values of 9.3 nM (FGFR1), 7.6 nM (FGFR2), 22 nM (FGFR4), and 290 nM (FGFR3) . It is a research tool used in vitro and in vivo to study FGFR-driven oncogenesis and targeted therapy in cancers such as urothelial carcinoma.
Product Specifications
CAS Number
1265229-25-1
Product Name Alternative
CH5183284, CH-5183284, CH 5183284, Inhibitor, FGFR1, FGFR, FF 284, FF284, FF-284, Fibroblast growth factor receptor, FGFR2, FGFR3, FGFR4, Debio1347, Debio-1347, Debio 1347, inhibit, Zoligratinib
Field of Research
Cardiovascular Research, Signal Transduction
Purity
95.28% (May vary between batches)
Solubility
Ethanol:1 mg/mL (2.81 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.61 mM) ; DMSO:66 mg/mL (185.2 mM)
Smiles
Cc1nc2ccc (cc2[nH]1) -n1ncc (C (=O) c2cc3ccccc3[nH]2) c1N
Molecular Formula
C20H16N6O
Molecular Weight
356.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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