XL388
XL388 is a potent and selective ATP-competitive mTOR inhibitor with an IC50 of 9.9 nM, demonstrating >1000-fold selectivity over related PI3K kinases. This small molecule is a valuable research tool for studying mTOR signaling in cancer, aging, and metabolic diseases, applicable in both cellular and animal models.
Product Specifications
CAS Number
1251156-08-7
Product Name Alternative
CYP2C9, Mammalian target of Rapamycin, Inhibitor, inhibit, mTORC2, mTORC1, mTOR, XL 388, XL-388, XL388, PI3Kα
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
99.39% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.39 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:22 mg/mL (48.3 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1c (F) c (ccc1C (=O) N1CCOc2ccc (cc2C1) -c1ccc (N) nc1) S (C) (=O) =O
Molecular Formula
C23H22FN3O4S
Molecular Weight
455.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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