GNE0877
GNE-0877 is a potent and selective small molecule inhibitor of LRRK2 kinase, exhibiting a Ki of 0.7 nM. It is a valuable research tool for investigating LRRK2 biology in cellular models and has been utilized in preclinical in vivo studies relevant to Parkinson's disease research.
Product Specifications
CAS Number
1374828-69-9
Product Name Alternative
Small molecule, brain-penetrant, oral, LRRK2, inhibit, liver microsomes, Leucine-rich repeat kinase 2, Inhibitor, GNE 0877, GNE0877, GNE-0877
Field of Research
Cell Biology
Purity
98.01% (May vary between batches)
Solubility
DMSO:45 mg/mL (132.62 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CNc1nc (Nc2cn (nc2C) C (C) (C) C#N) ncc1C (F) (F) F
Molecular Formula
C14H16F3N7
Molecular Weight
339.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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