Birabresib
Birabresib (MK-8628) is a potent, cell-permeable small molecule inhibitor targeting the BET bromodomain proteins BRD2, BRD3, and BRD4. It has demonstrated antitumor activity in preclinical studies, showing efficacy in both in vitro cellular assays and in vivo models of various cancers, including hematological malignancies and solid tumors.
Product Specifications
CAS Number
202590-98-5
Product Name Alternative
Epigenetic Reader Domain, EpigeneticReaderDomain, Inhibitor, inhibit, OTX 015, OTX015, OTX-015, OTX015 (MK 8628/Birabresib), MK 8628, MK 8628/Birabresib, MK8628, MK-8628, Birabresib, BRDs
Field of Research
Epigenetics & Chromatin
Purity
98.30% (May vary between batches)
Solubility
DMSO:255 mg/mL (518.3 mM) ; Ethanol:9.8 mg/mL (19.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.07 mM)
Smiles
CC=1C2=C (N3C ([C@H] (CC (NC4=CC=C (O) C=C4) =O) N=C2C5=CC=C (Cl) C=C5) =NN=C3C) SC1C
Molecular Formula
C25H22ClN5O2S
Molecular Weight
491.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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