LY-411575
LY-411575 is a potent and selective γ-secretase inhibitor, demonstrating low nanomolar IC50 values in both membrane and cell-based assays for suppressing Notch cleavage. It is widely used in vitro and in vivo to investigate the Notch signaling pathway in cancer, neurology, and developmental biology research.
Product Specifications
CAS Number
209984-57-6
Product Name Alternative
Apoptosis, Inhibitor, Gammasecretase, Gamma secretase, inhibit, Notch S3 cleavage, Notch, LY411575, LY-411575, LY 411575, γ secretase (cell-based), γ secretase (membrane-based), γ-secretase
Field of Research
Cell Biology, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
97.03% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.88 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:35.71 mg/mL (74.48 mM) ; Ethanol:11 mg/mL (22.94 mM)
Smiles
C[C@H] (NC (=O) [C@@H] (O) c1cc (F) cc (F) c1) C (=O) N[C@H]1c2ccccc2-c2ccccc2N (C) C1=O
Molecular Formula
C26H23F2N3O4
Molecular Weight
479.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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