KPT276
KPT276 is an orally active, selective inhibitor of nuclear export (SINE) that covalently and irreversibly binds to CRM1. It is used in preclinical research to study CRM1 inhibition in cancer models, demonstrating activity in both in vitro cell assays and in vivo xenograft studies.
Product Specifications
CAS Number
1421919-75-6
Product Name Alternative
CRM1, KPT276, KPT-276, KPT 276
Field of Research
Pharmacology & Drug Discovery
Purity
99.84% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:11 mg/mL (25.81 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.69 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
FC (F) (F) c1cc (cc (c1) C (F) (F) F) -c1ncn (C=CC (=O) N2CC (F) (F) C2) n1
Molecular Formula
C16H10F8N4O
Molecular Weight
426.26
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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