Sapitinib
Sapitinib (AZD-8931) is a potent, ATP-competitive inhibitor of EGFR, ErbB2, and ErbB3 with single-digit nM IC50 values. It demonstrates superior activity to gefitinib or lapatinib in NSCLC cells and exhibits high selectivity for the ErbB family over kinases like MNK1 and Flt. This compound is a valuable tool for in vitro and in vivo studies exploring ErbB signaling in cancer research.
Product Specifications
CAS Number
848942-61-0
Product Name Alternative
Sapitinib, AZD 8931, AZD8931, AZD-8931, Inhibitor, HER2/ErbB2, HER1, EGFR, Epidermal growth factor receptor, ErbB-1, inhibit
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.35% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.22 mM) ; DMSO:40 mg/mL (84.4 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CNC (=O) CN1CCC (CC1) Oc1cc2c (Nc3cccc (Cl) c3F) ncnc2cc1OC
Molecular Formula
C23H25ClFN5O3
Molecular Weight
473.93
Storage Conditions
-20°C
Notes
For research use only.
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