GNF-5837
GNF-5837 is a potent, orally active pan-TRK inhibitor targeting TrkA and TrkB with IC50 values of 8 nM and 12 nM, respectively. It is a valuable research tool for investigating TRK kinase signaling in cancer and neurological disease models, both in vitro and in vivo.
Product Specifications
CAS Number
1033769-28-6
Product Name Alternative
CKit, Inhibitor, GNF5837, GNF-5837, GNF 5837, Kit, inhibit, PDGFRβ, Tropomyosin related kinase receptor, Trk receptor, Trk Receptor, TrkA, TrkC, TrkB, Trkreceptor
Field of Research
Cardiovascular Research, Signal Transduction
Purity
96.17% (May vary between batches)
Solubility
DMSO:40 mg/mL (74.7 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.73 mM) ; Ethanol:5.4 mg/mL (10.08 mM)
Smiles
Cc1ccc (NC (=O) Nc2cc (ccc2F) C (F) (F) F) cc1Nc1ccc2\C (=C\c3ccc[nH]3) C (=O) Nc2c1
Molecular Formula
C28H21F4N5O2
Molecular Weight
535.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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