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Fostamatinib

Fostamatinib (R788) is a prodrug metabolized to the active Syk inhibitor R406, exhibiting an IC50 of 41 nM against Syk while showing no activity against Lyn. This inhibitor is utilized in research on immunology and oncology, with applications in both in vitro signaling studies and in vivo models of autoimmune and inflammatory diseases.

Product Specifications

CAS Number

901119-35-5

Product Name Alternative

Inhibit, Inhibitor, FLT3, Fms like tyrosine kinase 3, Fostamatinib, MonoamineTransporter, Monoamine Transporter, Monoamine transporter, A3, AdenosineReceptor, Adenosine transporter, Adenosine Receptor, CD135, Cluster of differentiation antigen 135, R 788, R788, R-788, Syk, Spleen tyrosine kinase

Field of Research

Cardiovascular Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Purity

93.08% (May vary between batches)

Solubility

DMSO:127.5 mg/mL (219.65 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.89 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

COc1cc (Nc2ncc (F) c (Nc3ccc4OC (C) (C) C (=O) N (COP (O) (O) =O) c4n3) n2) cc (OC) c1OC

Molecular Formula

C23H26FN6O9P

Molecular Weight

580.46

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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