Pralatrexate
Pralatrexate is a 10-deazaaminopterin analog and potent dihydrofolate reductase (DHFR) inhibitor with high affinity for the reduced folate carrier (RFC-1) . It is used in research for its antineoplastic properties, applied in studies of T-cell lymphomas both in vitro and in preclinical in vivo models.
Product Specifications
CAS Number
146464-95-1
Product Name Alternative
Folylpolyglutamate, Folotyn, Inhibitor, inhibit, p27, cytotoxicity, dihydrofolate, DHFR, Antifolate, antitumor, Apoptosis, AXL, 10-Propargyl-10-deazaaminopterin, synthetase, TAM Receptor, TAMReceptor, RFC-1, reductase, Pralatrexate
Field of Research
Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
94.32% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.19 mM) ; DMSO:250 mg/mL (523.59 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Nc1nc (N) c2nc (CC (CC#C) c3ccc (cc3) C (=O) N[C@@H] (CCC (O) =O) C (O) =O) cnc2n1
Molecular Formula
C23H23N7O5
Molecular Weight
477.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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