Mubritinib
Mubritinib (TAK-165) is a potent and selective small molecule inhibitor targeting the HER2/ErbB2 tyrosine kinase, demonstrating an IC50 of 6 nM. It has been utilized in preclinical research to investigate HER2-driven cancers, showing antitumor activity in both cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
366017-09-6
Product Name Alternative
PDGFR, JAK1, inhibit, Mubritinib, Inhibitor, HER2/ErbB2, HER1, ErbB-1, Epidermal growth factor receptor, EGFR, FGFR, TAK165, TAK-165, TAK 165
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.61% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:2 mg/mL (4.27 mM) ; DMSO:35.1 mg/mL (74.92 mM)
Smiles
FC (F) (F) c1ccc (\C=C\c2nc (COc3ccc (CCCCn4ccnn4) cc3) co2) cc1
Molecular Formula
C25H23F3N4O2
Molecular Weight
468.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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