Semagacestat
Semagacestat (LY450139) is a potent γ-secretase inhibitor that reduces Aβ peptide production (Aβ42/Aβ40/Aβ38) and inhibits Notch signaling with nanomolar IC50 values. It has been utilized in both in vitro and in vivo research models to investigate Alzheimer's disease pathology and Notch-related cellular processes.
Product Specifications
CAS Number
425386-60-3
Product Name Alternative
BetaAmyloid, Beta Amyloid, Amyloid-β, bAmyloid, b Amyloid, Abeta, LY 450139, LY450139, LY-450139, inhibit, Inhibitor, Notch, Gammasecretase, Gamma secretase, Semagacestat, β Amyloid, βAmyloid, β-amyloid peptide, γ secretase (Aβ42), γ secretase (Aβ38), γ secretase (Aβ40), γ-secretase
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
97.10% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (6.92 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:67 mg/mL (185.37 mM) ; Ethanol:39 mg/mL (107.9 mM)
Smiles
CC (C) [C@H] (O) C (=O) N[C@@H] (C) C (=O) N[C@H]1c2ccccc2CCN (C) C1=O
Molecular Formula
C19H27N3O4
Molecular Weight
361.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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