PHA-665752
PHA-665752 is a potent and selective ATP-competitive inhibitor of the c-Met receptor tyrosine kinase, exhibiting an IC50 of 9 nM. It demonstrates over 50-fold selectivity against other kinases. This compound is a valuable research tool for studying c-Met signaling in cancer models, both in cellular assays and in vivo studies.
Product Specifications
CAS Number
477575-56-7
Product Name Alternative
Flk1, FGFR1, HGFR, Inhibitor, inhibit, cMet, c-Met, cMet/HGFR, c-Met/HGFR, c-Abl, BcrAbl, Autophagy, Apoptosis, PHA 665752, PHA665752, PHA-665752, RON
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction
Purity
97.01% (May vary between batches)
Solubility
DMSO:50 mg/mL (77.93 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.12 mM)
Smiles
C (=C\1/C=2C (NC1=O) =CC=C (S (CC3=C (Cl) C=CC=C3Cl) (=O) =O) C2) \C4=C (C) C (C (=O) N5[C@@H] (CN6CCCC6) CCC5) =C (C) N4
Molecular Formula
C32H34Cl2N4O4S
Molecular Weight
641.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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