Dorsomorphin dihydrochloride
Dorsomorphin dihydrochloride (BML-275 2HCl) is a selective, ATP-competitive AMPK inhibitor (Ki=109 nM) that also blocks BMP receptors ALK2, ALK3, and ALK6. This compound induces autophagy and exhibits antitumor activity, making it a valuable tool for studying metabolic signaling, bone morphogenesis, and cancer biology in both cellular and animal models.
Product Specifications
CAS Number
1219168-18-9
Product Name Alternative
Inhibit, pathway, Inhibitor, Compound C Dihydrochloride, Compound C, Compound C 2HCl, Compound C dihydrochloride, Dorsomorphin, Dorsomorphin (Compound C), Dorsomorphin Dihydrochloride, Dorsomorphin dihydrochloride, Dorsomorphin (Compound C) 2HCl, AMPK, AMP-activated protein kinase, Autophagy, ATP-competitive, BML 275, BML 275 Dihydrochloride, BML275, BML-275, BML-275 2HCl, BML275 Dihydrochloride, BML-275 Dihydrochloride, BML-275 dihydrochloride, BMP, receptors, Smad, type, Transforming growth factor beta receptors, TGF-b/Smad, TGFb, TGFbeta/Smad, TGF-beta, TGFbeta, TGFβ, TGF-β Receptor, TGF-β/Smad
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.74% (May vary between batches)
Solubility
DMSO:7.4 mg/mL (15.66 mM) ; H2O:47.2 mg/mL (99.91 mM)
Smiles
Cl.Cl.C (CN1CCCCC1) Oc1ccc (cc1) -c1cnc2c (cnn2c1) -c1ccncc1
Molecular Formula
C24H25N5O·2HCl
Molecular Weight
472.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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