BI-2536
BI2536 is a potent and selective inhibitor of Polo-like kinase 1 (Plk1), exhibiting an IC50 of 0.83 nM with 4- and 11-fold selectivity over Plk2 and Plk3, respectively. This small molecule is a valuable research tool for studying cell cycle progression, mitotic regulation, and oncology in both in vitro and in vivo models.
Product Specifications
CAS Number
755038-02-9
Product Name Alternative
Field of Research
Cell Biology, Epigenetics & Chromatin, Protein Biochemistry
Purity
>97%
Bioactivity
Dual Plk/BRD4 inhibitor; Destabilizes Myc
Form
Powder
Solubility
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
Smiles
C (C) [C@H]1N (C=2C (N (C) C1=O) =CN=C (NC3=C (OC) C=C (C (NC4CCN (C) CC4) =O) C=C3) N2) C5CCCC5
Molecular Formula
C28H39N7O3
Molecular Weight
521.67
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[[ (7R) -8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N- (1-methylpiperidin-4-yl) benzamide
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