R406
R406 besylate is a potent and selective inhibitor of spleen tyrosine kinase (Syk), demonstrating an IC50 of 41 nM with no activity against Lyn. This small molecule is a valuable research tool for studying Syk-dependent signaling pathways in immune cell activation, inflammation, and oncology, both in vitro and in preclinical in vivo models.
Product Specifications
CAS Number
841290-81-1
Product Name Alternative
FLT3, Apoptosis, R 406, R406, R-406, Syk
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
97.67% (May vary between batches)
Solubility
Ethanol:8 mg/mL (12.73 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.36 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:100 mg/mL (159.08 mM)
Smiles
OS (=O) (=O) c1ccccc1.COc1cc (Nc2ncc (F) c (Nc3ccc4OC (C) (C) C (=O) Nc4n3) n2) cc (OC) c1OC
Molecular Formula
C22H23FN6O5·C6H6O3S
Molecular Weight
628.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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