ISRIB
ISRIB (trans-isomer) is a potent PERK inhibitor (IC50=5 nM) that reverses translational suppression and stress granule assembly induced by phosphorylated eIF2α. This small molecule is a valuable research tool for studying the integrated stress response in cellular and animal models of neurodegeneration and other diseases.
Product Specifications
CAS Number
1597403-47-8
Product Name Alternative
Trans-ISRIB
Field of Research
Neuroscience, Protein Biochemistry
Purity
>98%
Bioactivity
Integrated stress response inhibitor
Form
Powder
Solubility
DMSO (up to 5 mg/ml with warming)
Smiles
Clc1ccc (OCC (=O) N[C@H]2CC[C@@H] (CC2) NC (=O) COc2ccc (Cl) cc2) cc1
Molecular Formula
C22H24Cl2N2O4
Molecular Weight
451.34
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N.N’-trans-1,4-Cyclohexanediylbis[2- (4-chlorophenoxy) acetamide
Available Sizes
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