TRAM-34
TRAM-34 is a potent and selective inhibitor of the IKCa1 (KCa3.1) channel with a Kd of 20 nM, exhibiting 200-1500-fold selectivity over other ion channels and no cytochrome P450 blockade. Its utility in research extends to studying T-cell activation, vascular remodeling, and fibrosis in both cellular and animal models.
Product Specifications
CAS Number
289905-88-0
Product Name Alternative
IkB/IKK, IkB, IKCa1 (KCa3.1), IKK, Inhibitor, inhibit, KcsA, IκB, PotassiumChannel, Potassium Channel, TRAM 34, TRAM34, TRAM-34, Triarylmethane-34
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:3.5 mg/mL (10.15 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.9 mM)
Smiles
ClC1=C (C=CC=C1) C (N1C=CC=N1) (C1=CC=CC=C1) C1=CC=CC=C1
Molecular Formula
C22H17ClN2
Molecular Weight
344.84
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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