Monocrotaline
Monocrotaline is a macrocyclic pyrrolizidine alkaloid that inhibits organic cation transporters OCT-1 and OCT-2. It demonstrates cytotoxic effects against HepG2 liver cancer cells in vitro and is widely utilized to establish rodent models of pulmonary arterial hypertension for in vivo research.
Product Specifications
CAS Number
315-22-0
Product Name Alternative
Crotaline; MCT; NSC28693
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
Induces pulmonary fibrosis in animal models
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)
Smiles
O=C1O[C@]2 ([C@@]3 (N (CC2) CC=C3COC (=O) [C@] (C) (O) [C@] (C) (O) [C@H]1C) [H]) [H]
Molecular Formula
C16H23NO6
Molecular Weight
325.36
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(3R,4R,5R) -4,5,8,10,12,13,13aR,13bR-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6 (3H) -dione
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