MI-2-2
MI-2-2 is a potent, cell-permeable small molecule inhibitor that disrupts the menin-MLL protein-protein interaction, exhibiting an IC50 of 46 nM and a Kd of 22 nM for menin. It is a valuable chemical probe for studying menin-dependent transcriptional regulation in leukemia research, applicable in both cellular and biochemical assays.
Product Specifications
CAS Number
1454920-20-7
Product Name Alternative
MI 22, MI22, MI-22, MI-2-2, MI 2 2, inhibit, Epigenetic Reader Domain, Inhibitor, Hoxa9 expression, HistoneMethyltransferase, Histone Methyltransferase, leukemia, Menin-MLL, menin-MLL interaction, differentiation, cell proliferation
Field of Research
Epigenetics & Chromatin
Purity
99.56% (May vary between batches)
Solubility
DMSO:Soluble
Smiles
C (C (F) (F) F) C1=CC2=C (N=CN=C2S1) N3CCN (CC3) C=4SC (C) (C) CN4
Molecular Formula
C17H20F3N5S2
Molecular Weight
415.5
Storage Conditions
-20°C
Notes
For research use only.
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