NIBR-0213
NIBR-0213 is a potent, competitive, and selective S1P1 receptor antagonist, demonstrating IC50 values of 2.0 nM (human) and 2.3 nM (rat) in GTPγS binding assays. It shows efficacy in the experimental autoimmune encephalomyelitis (EAE) model, supporting its use in researching multiple sclerosis and other autoimmune disorders.
Product Specifications
CAS Number
1233332-14-3
Product Name Alternative
Autoimmune, encephalomyelitis, Inhibitor, inhibit, LPL Receptor, LPLReceptor, NIBR 0213, NIBR0213, NIBR-0213, Lysophospholipid Receptor, S1PR1, S1P1
Field of Research
Pharmacology & Drug Discovery
Purity
98.36% (May vary between batches)
Solubility
DMSO:55 mg/mL (118.28 mM)
Smiles
CC=1C=C (C=C (C) C1C (N[C@H] (C (O) =O) C) =O) C2=CC (N[C@H] (C) C3=CC (C) =C (Cl) C=C3) =CC=C2
Molecular Formula
C27H29ClN2O3
Molecular Weight
464.98
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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