Bicuculline
Bicuculline is a natural alkaloid that acts as a competitive GABAA receptor antagonist (IC50 = 2 μM) and a blocker of SK potassium channels. It is widely utilized in neuroscience research to induce seizures in animal models and to study synaptic inhibition and neuronal excitability in vitro.
Product Specifications
CAS Number
485-49-4
Product Name Alternative
Bicuculline, (+) -Bicuculline, AHP, alkaloid, d-Bicuculline, convulsant, competitive, inhibit, neurotransmitter, Inhibitor, GABAR, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, potassium, γ-Aminobutyric acid Receptor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.44 mM) ; DMSO:16.67 mg/mL (45.38 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
[H][C@]1 (OC (=O) c2c3OCOc3ccc12) [C@@]1 ([H]) N (C) CCc2cc3OCOc3cc12
Molecular Formula
C20H17NO6
Molecular Weight
367.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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