Bardoxolone
Bardoxolone methyl is a potent synthetic triterpenoid that activates the Nrf2 pathway and inhibits NF-κB signaling, leading to antioxidant and anti-inflammatory effects. It has been investigated in vitro for cancer research by inducing apoptosis and in vivo for conditions like chronic kidney disease and pulmonary arterial hypertension.
Product Specifications
CAS Number
218600-44-3
Product Name Alternative
Bardoxolone, CDDO, Nrf2, Inhibitor, Keap1-Nrf2, inhibit, RTA 401, RTA401, RTA-401
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology
Purity
97.90% (May vary between batches)
Solubility
DMSO:16 mg/mL (32.54 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.14 mM)
Smiles
CC1 (C) CC[C@@]2 (CC[C@]3 (C) [C@@H] ([C@H]2C1) C (=O) C=C1[C@@]2 (C) C=C (C#N) C (=O) C (C) (C) C2CC[C@@]31C) C (O) =O
Molecular Formula
C31H41NO4
Molecular Weight
491.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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