Apremilast
Apremilast (CC-10004) is an orally bioavailable, small-molecule PDE4 inhibitor exhibiting potent anti-inflammatory activity (IC50=74 nM) . It is widely used in research to investigate inflammatory pathways, with applications in both in vitro cellular assays and in vivo models of autoimmune and inflammatory diseases.
Product Specifications
CAS Number
608141-41-9
Product Name Alternative
Lipopolysaccharide, inhibit, LPS, PDE4, PBMC, nucleotide, orally, Inhibitor, Apremilast, Apoptosis, available, CC 10004, CC10004, CC-10004, cyclic, phosphodiesterase, Phosphodiesterase (PDE), TNFR, TNF Receptor, type-4, Tumor Necrosis Factor Receptor
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Purity
98.13% (May vary between batches)
Solubility
DMSO:58.33 mg/mL (126.67 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.17 mM)
Smiles
[C@H] (CS (C) (=O) =O) (N1C (=O) C=2C (C1=O) =CC=CC2NC (C) =O) C3=CC (OCC) =C (OC) C=C3
Molecular Formula
C22H24N2O7S
Molecular Weight
460.50
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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