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XL019

XL019 is a highly selective small molecule inhibitor of JAK2, exhibiting potent activity with an IC50 of 2.2 nM and demonstrating 100-fold selectivity against JAK1. It is a valuable research tool for studying JAK2-dependent signaling in cellular assays and has been utilized in preclinical models of myeloproliferative neoplasms.

Product Specifications

CAS Number

945755-56-6

Product Name Alternative

FLT3, Inhibitor, oral, inhibit, JAK2, JAK1, JAK, Janus kinase, JAK3, Apoptosis, antitumor, HEL.92.1.7, cells, tumor, PDGFRβ, selective, phosphorylation, XL 019, XL019, XL-019

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

99.19% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.5 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:13 mg/mL (29.24 mM)

Smiles

O=C (Nc1ccc (cc1) -c1ccnc (Nc2ccc (cc2) N2CCOCC2) n1) [C@@H]1CCCN1

Molecular Formula

C25H28N6O2

Molecular Weight

444.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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