PF-670462 dihydrochloride
PF-670462 is a highly potent and selective inhibitor of CK1ε, exhibiting an IC50 of 7.7 nM and over 30-fold selectivity against a broad kinase panel. This compound is a valuable chemical probe for studying circadian rhythms, Wnt/β-catenin signaling, and cancer biology in both cellular and animal models.
Product Specifications
CAS Number
950912-80-8
Product Name Alternative
Inhibitor, inhibit, Casein Kinase, CaseinKinase, CK1ε, PF-670462, PF670462, PF 670462
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
Casein kinase 1δ/ε inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
Cl.Cl.Nc1nccc (n1) -c1c (ncn1C1CCCCC1) -c1ccc (F) cc1
Molecular Formula
C19H22Cl2FN5
Molecular Weight
337.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[3-Cyclohexyl-5- (4-fluorophenyl) imidazol-4-yl]pyrimidin-2-amine 2HCl
Available Sizes
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