SGC0946
SGC0946 is a potent and selective DOT1L methyltransferase inhibitor with an IC50 of 0.3 nM. It induces selective cell death in MLL-rearranged leukemia cells and is a valuable chemical probe for studying histone methylation in both in vitro and in vivo cancer research models.
Product Specifications
CAS Number
1561178-17-3
Product Name Alternative
TOV21G, SGC 0946, SGC0946, SGC-0946, cord blood cells, DOT1L, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, leukemia, ovarian cancer, Molm13 MLL, MLL-rearrange, inhibit
Field of Research
Epigenetics & Chromatin
Purity
98.00% (May vary between batches)
Solubility
Ethanol:93 mg/mL (150.35 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.33 mM) ; DMSO:150 mg/mL (242.49 mM)
Smiles
CC (C) N (CCCNC (=O) Nc1ccc (cc1) C (C) (C) C) C[C@H]1O[C@H] ([C@H] (O) [C@@H]1O) n1cc (Br) c2c (N) ncnc12
Molecular Formula
C28H40BrN7O4
Molecular Weight
618.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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