PS-1145
PS-1145 is a potent and selective inhibitor of IκB kinase (IKK), exhibiting an IC50 of 88 nM. This small molecule is widely used in biochemical and cellular research to investigate NF-κB signaling pathways in both in vitro and in vivo models of inflammation and cancer.
Product Specifications
CAS Number
431898-65-6
Product Name Alternative
Apoptosis, IκB kinase, IκB, inhibit, IKK, IKK Inhibitor X, IkB/IKK, IkB, I kappa B kinase, Inhibitor, PS 1145, PS1145, PS-1145
Field of Research
Cell Biology, Signal Transduction
Purity
97.06% (May vary between batches)
Solubility
DMSO:50 mg/mL (154.92 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+90% Corn Oil:2.5 mg/mL (7.75 mM) ; Ethanol:2 mg/mL (6.2 mM)
Smiles
Clc1cc (NC (=O) c2cccnc2) c2[nH]c3cnccc3c2c1
Molecular Formula
C17H11ClN4O
Molecular Weight
322.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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