Pinometostat
Pinometostat (EPZ-5676) is a highly potent and selective DOT1L histone methyltransferase inhibitor with a Ki of 80 pM. It is widely used in leukemia research, demonstrating antitumor activity in both in vitro and in vivo models for diseases like MLL-rearranged leukemia.
Product Specifications
CAS Number
1380288-87-8
Product Name Alternative
DOT1L, Inhibitor, Histone Methyltransferase, HistoneMethyltransferase, EPZ5676, EPZ-5676, EPZ 5676, inhibit, Pinometostat
Field of Research
Epigenetics & Chromatin
Purity
97.56% (May vary between batches)
Solubility
DMSO:100 mg/mL (177.71 mM) ; Ethanol:85 mg/mL (151.05 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.11 mM)
Smiles
O[C@H]1[C@H] (N2C=3C (N=C2) =C (N) N=CN3) O[C@H] (CN (C (C) C) [C@H]4C[C@@H] (CCC=5NC=6C (N5) =CC=C (C (C) (C) C) C6) C4) [C@H]1O
Molecular Formula
C30H42N8O3
Molecular Weight
562.71
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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