Ciliobrevin A
Ciliobrevin A (HPI-4) is a cell-permeable small molecule inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 below 10 μM. It is widely used in both in vitro and in vivo research to study ciliary function, developmental biology, and Hedgehog-related oncogenesis.
Product Specifications
CAS Number
302803-72-1
Product Name Alternative
Ciliobrevin A, Hedgehog Pathway Inhibitor 4, Hedgehog, Inhibitor, HPI 4, HPI4, HPI-4, inhibit, Smoothened
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
97.10% (May vary between batches)
Solubility
Ethanol:1 mg/mL (2.79 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.58 mM) ; DMSO:65 mg/mL (181.47 mM)
Smiles
Clc1ccc (C (=O) C (\C#N) =C2\NC (=O) c3ccccc3N2) c (Cl) c1
Molecular Formula
C17H9Cl2N3O2
Molecular Weight
358.18
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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