COH29
COH29 is an orally bioavailable thiazole derivative that acts as a ribonucleotide reductase (RNR) inhibitor, targeting the hRRM2 subunit to deplete dNTP pools and impair DNA synthesis. It has demonstrated antineoplastic activity in vitro and in vivo, showing potential in cancer research, particularly in studies involving DNA replication stress and PARP1 inhibition.
Product Specifications
CAS Number
1190932-38-7
Product Name Alternative
Ribonucleotide, RNA Synthesis, RNR, RNR Inhibitor COH 29, RNR Inhibitor COH29, RNR Inhibitor COH-29, RNR (KB cell), RNASynthesis, subunit, COH 29, COH29, COH-29, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis
Field of Research
Cell Biology, Molecular Biology
Purity
97.04% (May vary between batches)
Solubility
DMSO:50 mg/mL (118.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.76 mM)
Smiles
Oc1ccc (cc1O) C (=O) Nc1nc (c (s1) -c1ccccc1) -c1ccc (O) c (O) c1
Molecular Formula
C22H16N2O5S
Molecular Weight
420.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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