L-778123 hydrochloride
L-778123 hydrochloride is a dual inhibitor of farnesyltransferase (FPTase, IC50 = 2 nM) and geranylgeranyltransferase-I (GGPTase-I, IC50 = 98 nM) . This compound has been utilized in vitro and in vivo to investigate the role of protein prenylation in Ras-related cancer pathways and signal transduction research.
Product Specifications
CAS Number
253863-00-2
Product Name Alternative
L 778123, Ftase, Farnesyl Transferase, FPTase, L-778,123, L778123, L-778123 Hydrochloride, L-778123
Field of Research
Metabolism Research, Molecular Biology
Purity
93.93% (May vary between batches)
Solubility
PBS:100 mg/mL (226.07 mM) ; DMSO:200 mg/mL (452.14 mM)
Smiles
Cl.Clc1cccc (c1) N1CCN (Cc2cncn2Cc2ccc (cc2) C#N) CC1=O
Molecular Formula
C22H21Cl2N5O
Molecular Weight
442.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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