R112
R112 is a potent and selective ATP-competitive inhibitor of spleen tyrosine kinase (Syk), exhibiting a Ki of 6 nM and an IC50 of 226 nM. This small molecule is a valuable research tool for studying Syk-dependent signaling pathways in immunology and oncology, applicable in both in vitro biochemical assays and cellular research models.
Product Specifications
CAS Number
575474-82-7
Product Name Alternative
Tryptase, TNF-α, reversible, Spleen tyrosine kinase, Syk, R112, R-112, R 112, phosphorylation, LTC4, IL-8, inhibit, GM-CSF, Elafibranor, fast, Inhibitor, histamine, basophil, allergic rhinitis, (E) -Elafibranor
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.06% (May vary between batches)
Solubility
DMSO:55 mg/mL (176.11 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.4 mM)
Smiles
Oc1cccc (Nc2ncc (F) c (Nc3cccc (O) c3) n2) c1
Molecular Formula
C16H13FN4O2
Molecular Weight
312.3
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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