AMG-337
AMG-337 is a potent and selective ATP-competitive inhibitor of the MET kinase, demonstrating an IC50 of less than 5 nM in enzymatic assays. It is a valuable research tool for investigating MET-driven pathologies in both cellular and animal models, with applications in oncology and cancer research.
Product Specifications
CAS Number
1173699-31-4
Product Name Alternative
Anticancer, AMG 337, AMG337, AMG-337, cell proliferation, cMet, c-Met, c-Met/HGFR, cMet/HGFR, inhibit, Inhibitor, MKN-45, Met, Met (H1094R), Met (M1250T), Met (V1092I), Met (Y1230H), HGFR, phosphorylation, SNU-5 cells, SNU-620
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction
Purity
99.26% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.32 mM) ; Ethanol:95 mg/mL (204.98 mM) ; DMSO:50 mg/mL (107.88 mM)
Smiles
COCCOc1cnc2ccn ([C@H] (C) c3nnc4c (F) cc (cn34) -c3cnn (C) c3) c (=O) c2c1
Molecular Formula
C23H22FN7O3
Molecular Weight
463.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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