AKB-6899
AKB-6899 is a PHD3 inhibitor that stabilizes HIF-2α, thereby enhancing sVEGFR-1 production in macrophages. This mechanism has been shown to suppress tumor growth in vivo, making it a valuable research tool for studying hypoxia signaling, tumor immunology, and angiogenesis in both cellular and animal models.
Product Specifications
CAS Number
1007377-55-0
Product Name Alternative
Hypoxia-inducible factors, HIFs, HIF-PH, HIFProlylHydroxylase, HIF-2α, HIF ProlylHydroxylase, HIF, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, Inhibitor, inhibit, antiangiogenic, antitumor, AKB 6899, AKB6899, AKB-6899, PHD3, sVEGFR-1, VEGFR1
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Signal Transduction
Purity
97.11% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.37 mM) ; DMSO:95 mg/mL (327.3 mM)
Smiles
OC (=O) CNC (=O) c1ncc (cc1O) -c1cccc (F) c1
Molecular Formula
C14H11FN2O4
Molecular Weight
290.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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