Olaparib
Olaparib is a potent, selective, and orally bioavailable inhibitor of PARP1 and PARP2, with significantly weaker activity against tankyrase-1. It is widely used in cancer research, particularly in studies of BRCA-deficient tumors, and has been shown to induce autophagy and mitophagy in both cellular and animal models.
Product Specifications
CAS Number
763113-22-0
Product Name Alternative
Autophagy, AZD 2281, AZD2281, AZD-2281, PARP, PARP1, PARP2, Mitophagy, Mitochondrial Autophagy, Olaparib, orally, poly ADP ribose polymerase, inhibit, Inhibitor, KU 0059436, KU0059436, KU-0059436
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (18.41 mM) ; H2O:< 1 mg/mL (insoluble) ; DMSO:82.5 mg/mL (189.89 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
C (C=1C=2C (C (=O) NN1) =CC=CC2) C3=CC (C (=O) N4CCN (C (=O) C5CC5) CC4) =C (F) C=C3
Molecular Formula
C24H23FN4O3
Molecular Weight
434.46
Storage Conditions
-20°C
Notes
For research use only.
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