MAP4K4-IN-3

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].

Product Specifications

CAS Number

[1811510-58-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/map4k4-in-3.html

Purity

99.15

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC=C(C2=CC(C3=CC=C(Cl)C=C3)=C(N)N=C2)C=N1

Molecular Formula

C15H12ClN5

Molecular Weight

297.74

Precautions

H302, H315, H319

References & Citations

[1]Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6 (11) :1128-33.|[2]Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61 (7) :3114-3125.