MAP4K4-IN-3
MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].
Product Specifications
CAS Number
1811510-58-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/map4k4-in-3.html
Purity
99.15
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC=C(C2=CC(C3=CC=C(Cl)C=C3)=C(N)N=C2)C=N1
Molecular Formula
C15H12ClN5
Molecular Weight
297.74
Precautions
H302, H315, H319
References & Citations
[1]Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6 (11) :1128-33.|[2]Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61 (7) :3114-3125.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK
Available Sizes
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