MAP4K4-IN-3
Product Specifications
UNSPSC Description
MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].
Target Antigen
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/map4k4-in-3.html
Purity
99.15
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
NC1=NC=C(C2=CC(C3=CC=C(Cl)C=C3)=C(N)N=C2)C=N1
Molecular Weight
297.74
References & Citations
[1]Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.|[2]Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125012/MAP4K4-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125012/MAP4K4-IN-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1811510-58-3
Available Sizes
Curated Selection
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