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VU0357017 hydrochloride

VU0357017 hydrochloride is a highly selective, allosteric agonist of the M1 muscarinic receptor with an EC50 of 477 ± 172 nM. This research compound is utilized in vitro and in vivo to investigate M1 receptor function in contexts such as cognitive disorders and central nervous system research.

Product Specifications

CAS Number

1135242-13-5

Product Name Alternative

Muscarinic acetylcholine receptor, muscarinic, inhibit, M1 mAChR, mAChR, ML071 hydrochloride, ML071 Hydrochloride, ML-071 Hydrochloride, ML 071 Hydrochloride, Inhibitor, CID25010775, CID-25010775, CID 25010775, acetylcholine, Alzheimer's, VU0357017, VU-0357017, VU0357017 Hydrochloride, VU0357017 hydrochloride, VU-0357017 Hydrochloride, VU-0357017 hydrochloride, VU 0357017, VU 0357017 hydrochloride, VU 0357017 Hydrochloride, schizophrenia

Field of Research

Neuroscience

Purity

99.00% (May vary between batches)

Solubility

DMSO:33 mg/mL (89.22 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.41 mM)

Smiles

Cl.CCOC (=O) N1CCC (CC1) NCCNC (=O) c1ccccc1C

Molecular Formula

C18H28ClN3O3

Molecular Weight

369.89

References & Citations

Paulina Cieślik 1, Anna Rafało-Ulińska 1, Joanna M Wierońska Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice Pharmacol Biochem Behav, (2024)

Pubmed id

38462045

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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