Cobimetinib
Cobimetinib (GDC-0973) is a potent and selective oral MEK1 inhibitor (IC50=4.2 nM) . It demonstrates antitumor efficacy by suppressing proliferation and promoting apoptosis in tumor cells, as validated in both cellular assays and in vivo xenograft models for cancer research.
Product Specifications
CAS Number
934660-93-2
Product Name Alternative
XL 518, XL518, XL-518, RG 7420, RG7420, RG-7420, Mitogen-activated protein kinase kinase, inhibit, Inhibitor, GDC 0973, GDC0973, GDC-0973, MAP2K, MEK1, MEK, MAPKK, Apoptosis, Cobimetinib
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.76 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:44 mg/mL (82.81 mM) ; DMSO:84.17 mg/mL (158.42 mM)
Smiles
C (=O) (C1=C (NC2=C (F) C=C (I) C=C2) C (F) =C (F) C=C1) N3C[C@] (O) (C3) [C@@H]4CCCCN4
Molecular Formula
C21H21F3IN3O2
Molecular Weight
531.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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