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Cobimetinib

Cobimetinib (GDC-0973) is a potent and selective oral MEK1 inhibitor (IC50=4.2 nM) . It demonstrates antitumor efficacy by suppressing proliferation and promoting apoptosis in tumor cells, as validated in both cellular assays and in vivo xenograft models for cancer research.

Product Specifications

CAS Number

934660-93-2

Product Name Alternative

XL 518, XL518, XL-518, RG 7420, RG7420, RG-7420, Mitogen-activated protein kinase kinase, inhibit, Inhibitor, GDC 0973, GDC0973, GDC-0973, MAP2K, MEK1, MEK, MAPKK, Apoptosis, Cobimetinib

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.00% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.76 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:44 mg/mL (82.81 mM) ; DMSO:84.17 mg/mL (158.42 mM)

Smiles

C (=O) (C1=C (NC2=C (F) C=C (I) C=C2) C (F) =C (F) C=C1) N3C[C@] (O) (C3) [C@@H]4CCCCN4

Molecular Formula

C21H21F3IN3O2

Molecular Weight

531.31

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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