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Acalabrutinib

Acalabrutinib (ACP-196) is an oral Bruton's tyrosine kinase (BTK) inhibitor used in research for B-cell malignancies. It blocks BCR signaling, inhibiting malignant B-cell proliferation and survival. This small molecule is applied in both in vitro and in vivo studies of diseases like chronic lymphocytic leukemia and mantle cell lymphoma.

Product Specifications

CAS Number

1420477-60-6

Product Name Alternative

ACP-196

Field of Research

Immunology & Inflammation

Purity

>98%

Bioactivity

Highly selective BTK inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to at least 25 mg/ml)

Smiles

CC#CC (=O) N1CCC[C@H]1c1nc (-c2ccc (cc2) C (=O) Nc2ccccn2) c2c (N) nccn12

Molecular Formula

C26H23N7O2

Molecular Weight

465.52

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

4-[8-Amino-3-[ (2S) -1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide

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