Acalabrutinib
Acalabrutinib (ACP-196) is an oral Bruton's tyrosine kinase (BTK) inhibitor used in research for B-cell malignancies. It blocks BCR signaling, inhibiting malignant B-cell proliferation and survival. This small molecule is applied in both in vitro and in vivo studies of diseases like chronic lymphocytic leukemia and mantle cell lymphoma.
Product Specifications
CAS Number
1420477-60-6
Product Name Alternative
ACP-196
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
Highly selective BTK inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
CC#CC (=O) N1CCC[C@H]1c1nc (-c2ccc (cc2) C (=O) Nc2ccccn2) c2c (N) nccn12
Molecular Formula
C26H23N7O2
Molecular Weight
465.52
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[8-Amino-3-[ (2S) -1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide
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