Crenigacestat
Crenigacestat (LY3039478) is a potent, orally bioavailable small molecule inhibitor of Notch signaling, demonstrating an IC50 of ~1 nM in various tumor cell lines. It effectively suppresses mutant Notch receptor activity and, in xenograft models, reduces Notch target gene expression and N1ICD cleavage within tumors. This inhibitor is a valuable research tool for studying Notch pathway roles in cancer and other diseases in both in vitro and in vivo settings.
Product Specifications
CAS Number
1421438-81-4
Product Name Alternative
Gamma secretase, Gammasecretase, LY3039478, LY-3039478, LY 3039478, liver, Notch-1, Notch, inhibit, Inhibitor, CCRCC, Crenigacestat, γ-secretase
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
97.27% (May vary between batches)
Solubility
DMSO:150 mg/mL (322.97 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.31 mM)
Smiles
C[C@H] (NC (=O) CCC (F) (F) F) C (=O) N[C@H]1c2ccccc2-c2cccnc2N (CCO) C1=O
Molecular Formula
C22H23F3N4O4
Molecular Weight
464.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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