(E) -SIS3
(E) -SIS3 is a selective small molecule inhibitor of Smad3 with an IC50 of 3 μM. It effectively blocks TGF-β1-induced fibroblast-to-myofibroblast differentiation, making it a valuable research tool for studying fibrotic diseases in both cellular and animal models.
Product Specifications
CAS Number
521984-48-5
Product Name Alternative
(E) SIS3, (E) SIS3, (E) -SIS3, (E) -SIS-3, Smad3, Smad, SIS 3, SIS3, SIS-3, SIS3 HCl, SIS3 hydrobromide, TGFβ, TGF-β/Smad, TGFbeta, TGF-beta, TGF-beta/Smad, TGFbeta/Smad, TGF-b/Smad, TGFb, Transforming growth factor beta
Field of Research
Stem Cell & Developmental Biology
Purity
95.64% (May vary between batches)
Solubility
Ethanol:23 mg/mL (46.94 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:100 mg/mL (204.09 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.73 mM)
Smiles
Cl.COc1cc2CCN (Cc2cc1OC) C (=O) \C=C\c1c (-c2ccccc2) n (C) c2ncccc12
Molecular Formula
C28H27N3O3·HCl
Molecular Weight
489.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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