GW4869
GW4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinase (N-SMase) with an IC50 of 1 μM. It is widely used in both in vitro and in vivo research to block ceramide-mediated exosome biogenesis and secretion, making it a key pharmacological tool for studying extracellular vesicle biology and intercellular communication.
Product Specifications
CAS Number
6823-69-4
Product Name Alternative
Phospholipase, inhibit, Inhibitor, neutral sphingomyelinase, GW 4869, GW4869, GW-4869, GW554869A, GW69A
Field of Research
Metabolism Research
Purity
98.12% (May vary between batches)
Solubility
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cl.Cl.O=C (Nc1ccc (cc1) C1=NCCN1) \C=C\c1ccc (\C=C\C (=O) Nc2ccc (cc2) C2=NCCN2) cc1
Molecular Formula
C30H30Cl2N6O2
Molecular Weight
577.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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