ISO-1
ISO-1 is a small molecule MIF antagonist that inhibits dopachrome tautomerase activity. It suppresses NF-κB activation and TNF-α secretion in LPS-stimulated macrophages, making it a valuable tool for studying inflammation, sepsis, and autoimmune diseases in both cellular and animal models.
Product Specifications
CAS Number
478336-92-4
Product Name Alternative
Dopachrome tautomerase, MIF Antagonist, inhibit, ISO 1, ISO1, ISO-1, Inhibitor
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
Macrophage migration inhibitory factor (MIF) antagonist
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) .
Smiles
COC (=O) CC1CC (=NO1) c1ccc (O) cc1
Molecular Formula
C12H13NO4
Molecular Weight
235.24
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(S, R) -3- (4-Hydroxyphenyl) -4,5-dihydro-5-isoxazole acetic acid, methyl ester
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