A-740003
A-740003 is a potent and selective P2X7 receptor antagonist with IC50 values of 18 nM (rat) and 40 nM (human) . It has demonstrated efficacy in reducing pain in rodent models of neuropathic and inflammatory pain and has also been shown to inhibit neuroblastoma tumor growth in vivo.
Product Specifications
CAS Number
861393-28-4
Product Name Alternative
A740003, A-740003, A 740003, inhibit, Inhibitor, P2X Receptor, P2X7 (Human), P2XRs, P2XReceptor, rat P2X7
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
96.53% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.11 mM) ; DMSO:9.5 mg/mL (20.02 mM)
Smiles
COc1ccc (CC (=O) NC (N\C (Nc2cccc3ncccc23) =N\C#N) C (C) (C) C) cc1OC
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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