XMD8-87
XMD8-87 (ACK1-B19) is a potent and selective small molecule inhibitor of TNK2 (ACK1) kinase activity, effectively blocking its autophosphorylation. This compound, along with the analog XMD16-5, suppresses oncogenic TNK2 truncation mutants and is a valuable chemical probe for studying ACK1 signaling in cancer cell lines and in vivo tumor models.
Product Specifications
CAS Number
1234480-46-6
Product Name Alternative
ACK1-B19, Inhibitor, inhibit, XMD887, XMD-8-87, XMD8-87, XMD8 87, TNK2, Tyrosinase
Field of Research
Metabolism Research, Molecular Biology, Protein Biochemistry
Purity
97.12% (May vary between batches)
Solubility
Ethanol:5 mg/mL (11.22 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:5.33 mg/mL (11.96 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.24 mM)
Smiles
COc1cc (ccc1Nc1ncc2NC (=O) c3ccccc3N (C) c2n1) N1CCN (C) CC1
Molecular Formula
C24H27N7O2
Molecular Weight
445.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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